% PDFLaTeX
\documentclass[10pt]{article}
 
\usepackage{array}
\usepackage{calc}
\usepackage{ucs}
\usepackage[utf8x]{inputenc}
 
\begin{document}
{ \setlength{\tabcolsep}{2pt}
  \begin{tabular}{|>{\centering}m{3.5em}|>{\centering}m{4.5em}|>{\centering}m{6em}|>{\small}m{\textwidth-3.5em-4.5em-6em-8\tabcolsep-5\arrayrulewidth}|}
    \hline
    \textbf{Année} & \textbf{Nom} & \textbf{Appellation} & \multicolumn{1}{|c|}{\textbf{Apports majeurs}} \tabularnewline
    \hline
    2000 & Le nom complet & l'appellation & bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla bla \tabularnewline
    \hline
  \end{tabular}
}
\end{document}